NUMERO: #20250403

Título: A RARE AND AGGRESSIVE CASE OF METASTATIC COLONIC ADENOCARCINOMA PRESENTING IN THE ORAL CAVITY

Nome do Apresentador: Moisés Willian Aparecido GONÇALVES

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Patologia Oral

Resumo: Oral metastases from colorectal cancer are rare and have a poor prognosis. A 55-year-old woman was referred to the medical service to evaluate a painful lesion in the retromolar trigone. During the medical interview, the patient reported colonic adenocarcinoma (CA) with metastases in multiple organs. The extraoral examination showed a hardened enlargement on the left hemiface. Intraoral examination revealed an infiltrative ulcerative vegetative lesion in the left retromolar trigone. Computed tomography demonstrated an expansive lesion with a lytic component and cortical discontinuity in the left ascending mandibular ramus. Microscopic analysis showed a proliferative epithelial component composed of irregular tubular structures lined by columnar cells with variable pleomorphism. Immunohistochemical analysis showed positive staining for CK20 and CDX2, while CK7 was negative. The Ki-67 index was 90%. The diagnosis of metastatic CA to the oral cavity was confirmed. The patient was already undergoing palliative treatment. Funding: FAPESP-2023/14770-4

Autor 1:  Moisés Willian Aparecido GONÇALVES

E-mail 1:  [email protected]

Autor 2:   Gustavo de Souza VIEIRA

E-mail 2:  [email protected]

Autor 3 :  Tayná Figueiredo MACIEL

E-mail 3:  [email protected]

Autor 4:  Iara Vieira FERREIRA

E-mail 4:  [email protected]

Autor 5:  Carlos Takahiro CHONE

E-mail 5:  [email protected]

Autor 6:  Albina ALTEMANI

E-mail 6:  [email protected]

Autor 7:  Fernanda Viviane MARIANO

E-mail 7:  [email protected]