NUMERO: #20250379

Título: SEVERE MUCOCUTANEOUS PEMPHIGUS VULGARIS: DIAGNOSTIC AND THERAPEUTIC CHALLENGES

Nome do Apresentador: Liliane Novaes Joaquim

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Estomatologia

Resumo: A 47-year-old female patient presented with painful ulcerated and blistering lesions affecting the oral
mucosa and skin, with a five-month duration, suggestive of an autoimmune disorder. Initially, the
lesions were localized with lower morbidity; however, the condition progressed. Given the lack of
response to systemic corticosteroid therapy and the severity of the clinical presentation, characterized
by a 48-hour period of fever and without oral intake, the patient was hospitalized for clinical
stabilization and subsequently underwent a biopsy. Histopathological analysis of a periumbilical skin
lesion revealed suprabasal acantholytic bullous dermatosis, consistent with pemphigus vulgaris.
Treatment with high doses of corticosteroids and immunosuppressants resulted in clinical
improvement. The patient has been under follow-up for one year, showing partial remission. Early
diagnosis of pemphigus vulgaris allows for timely initiation of therapy, helping to prevent disease
dissemination and reducing the risk of mortality due to infections and treatment-related complications.

Autor 1:  Liliane Novaes Joaquim

E-mail 1:  [email protected]

Autor 2:   Nayara Fleury de Castro

E-mail 2:  [email protected]

Autor 3 :  Italo Tomonari Kano

E-mail 3:  [email protected]

Autor 4:  Nathalia Souza Andrade

E-mail 4:  [email protected]

Autor 5:  Norberto Nobuo Sugaya

E-mail 5:  [email protected]

Autor 6:  Camila de Barros Gallo

E-mail 6:  [email protected]