NUMERO: #20250361

Título: HIGH ORAL CANDIDA BURDEN CORRELATES WITH INCREASED PULMONARY DAMAGE IN TUBERCULOSIS PATIENTS

Nome do Apresentador: Alan Grupioni LOURENÇO

Categoria do Trabalho: Painel de pesquisa científica (PPC)

Área Temática: Estomatologia

Resumo: Introduction: Oral fungal burden by Candida spp. has been associated with the progression of several severe systemic diseases. However, no evidence to date links this colonization to the severity or prognosis of tuberculosis (TB).
Objective: To investigate the association between oral fungal burden and the prevalence of Candida spp. with the clinical severity of TB.
Methods: Saliva and oral rinse samples were collected from 151 TB patients at two time points: (T1) within 30 days of initiating treatment and (T2) after 150 days. Fungal burden and Candida species prevalence were analyzed in relation to four systemic indicators of TB severity: pulmonary extension, sputum smear positivity, Bandim TB Score, and the presence of extrapulmonary TB.
Results: A significant association was observed between greater pulmonary severity and increased oral Candida burden (p=0.035), as well as higher species diversity (p=0.04). Sputum smear positivity was also associated with greater species diversity (p=0.02). Patients with latent TB had the lowest fungal burden, while those with pulmonary TB had the highest levels.
Conclusion: Oral fungal burden by Candida spp. may serve as a complementary marker of TB severity.
FAPESP (Processo 2023/02205-0)

Autor 1:  Renata Klemp ORLANDINI

E-mail 1:  [email protected]

Autor 2:   Claúdia Helena Lovato da SILVA

E-mail 2:  [email protected]

Autor 3 :  Ana Carolina Fragoso MOTTA

E-mail 3:  [email protected]

Autor 4:  Evandro WATANABE

E-mail 4:  [email protected]

Autor 5:  Cinara Silva FELICIANO

E-mail 5:  [email protected]

Autor 6:  Valdes Roberto BOLLELA

E-mail 6:  [email protected]

Autor 7:  Alan Grupioni LOURENÇO

E-mail 7:  [email protected]