NUMERO: #20250339

Título: PRIMARY INTRAOSSEOUS ATYPICAL NON-NEURAL GRANULAR CELL TUMOR OF THE MANDIBLE: a detailed immunohistochemical study.

Nome do Apresentador: Marcelo Borges MARQUES

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Patologia Oral

Resumo: Unlike granular cell tumor (GCT), non-neural GCT (NN-GCT), is a distinctive neoplasm, characterized by uniform S100 negativity. To date, about 9 intraoral cases of NN-GCT have been reported. In the jaws, only 1 case of primary intraosseous maxillary GCT was published. A 31-year-old woman presented an osteolytic lesion on the right mandibular ramus 2 years ago. After incisional biopsy, microscopy revealed a diffuse proliferation of epithelioid and spindle cells, containing intracytoplasmic granules, focally exhibiting nuclear and cellular pleomorphism. By immunohistochemistry, the granular cells were positive for vimentin, NKI/C3, FXIIIA, CD10, and CD56 (focal). The p53 showed a wild-type pattern, and Ki-67 was 3%. All other markers (pan-CK, CK8/18, EMA, CD138, α-SMA, desmin, HMB-45, Melan-A, calponin, h-caldesmon, ERG, D2-40, ALK, cyclin D1, Glut-1, CD1a, CD11c, CD31, CD34, CD68, CD117, CD163, and CD207), and notably S100, were negative. To our knowledge, this is the first case of intraosseous NN-GCT affecting the jaws.

Autor 1:  Marcelo Borges MARQUES

E-mail 1:  [email protected]

Autor 2:   Nilson Coelho da Silva Filho

E-mail 2:  [email protected]

Autor 3 :  Karina Hellen Martins

E-mail 3:  [email protected]

Autor 4:  Luana Stefanie Silvino Gonçalves

E-mail 4:  [email protected]

Autor 5:  Mariangela Ottoboni Brunaldi

E-mail 5:  [email protected]

Autor 6:  Fernando Chahud

E-mail 6:  [email protected]

Autor 7:  Jorge Esquiche León

E-mail 7:  [email protected]