NUMERO: #20250335

Título: PREVENTIVE TREATMENTS FOR MEDICATION-RELATED OSTEONECROSIS: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS

Nome do Apresentador: Lucas Nascimento RIBEIRO

Categoria do Trabalho: Painel de Revisões narrativas ou sistemáticas (PRN)

Área Temática: Estomatologia

Resumo: Objective: A systematic review and network meta-analysis were conducted to address the following research question: "What is the most effective preventive treatment to reduce the risk of jaw osteonecrosis after tooth extraction in patients with a history of medication use associated with osteonecrosis?" Study Design: Randomized clinical trials conducted in adults with a history of medication use associated with osteonecrosis of the jaw, who were treated with a preventive method to reduce the risk of osteonecrosis after tooth extraction, were included. Risk of bias and quality of evidence were assessed using the Cochrane Collaboration tool. Bayesian random-effects mixed treatment comparison model was employed to compare all evaluated strategies: regenerative therapy, primary closure, secondary closure, epiperiosteal flap, and ozone infiltration. The network meta-analysis results were presented as point estimates with 95% credible intervals. Results: Five randomized clinical trials conducted between 2012 and 2024 were included. These studies evaluated various interventions, including platelet-rich fibrin, platelet-rich plasma, oxygen-ozone therapy, and different surgical closure techniques. Bayesian network meta-analysis demonstrated no conclusive evidence of superiority for any intervention over primary closure. Conclusion: No preventive strategy demonstrated superiority in reducing the risk of medication-related osteonecrosis of the jaw in patients undergoing tooth extraction.

Autor 1:  Lucas Nascimento RIBEIRO

E-mail 1:  [email protected]

Autor 2:   Raisa Severino-LAZO

E-mail 2:  [email protected]

Autor 3 :  Belmiro Cavalcanti do Egito VASCONCELOS

E-mail 3:  [email protected]

Autor 4:  Sandra Lúcia Dantas de MORAES

E-mail 4:  [email protected]

Autor 5:  Marianne de Vasconcelos CARVALHO

E-mail 5:  [email protected]