NUMERO: #20250315

Título: PEMPHIGUS VULGARIS - CASE REPORT

Nome do Apresentador: Luan Marcos CICHOSKI

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Patologia Oral

Resumo: ABSTRACT
INTRODUCTION: Pemphigus vulgaris is an autoimmune disease that, if left untreated, can lead to death. Oral lesions are often the first clinical manifestation. The disease is characterized by blister formation due to the abnormal production of autoantibodies directed against epidermal cell glycoproteins-desmoglein 3 and 1-which are components of desmosomes. These autoantibodies bind to them, inhibiting the molecular interaction responsible for cell adhesion. As a result of this autoimmune attack on desmosomes, a cleft forms within the epithelium, leading to the development of an intraepithelial blister. Clinically, patients present with painful erosions and irregular ulcers randomly distributed across the oral mucosa. CLINICAL CASE: Patient R.R.R., 33 years old, was diagnosed 10 months ago after the appearance of wounds on the body, including in the mouth. The patient reported painful and erosive lesions. Palliative treatment was performed using laser therapy.
Keywords: Pemphigus vulgaris, Autoimmune disease, Lesions, Desmoglein

Autor 1:  Luan Marcos CICHOSKI

E-mail 1:  [email protected]

Autor 2:   Felipe Silva de Lima OUTEIRO

E-mail 2:  [email protected]

Autor 3 :  Bruno Mateus CENCI

E-mail 3:  [email protected]

Autor 4:  Gláucia Renee HILGEMBERG

E-mail 4:  [email protected]

Autor 5:  Mario Ricardo KOWALCZUK

E-mail 5:  [email protected]