NUMERO: #20250298

Título: PROGNOSTIC VALUE OF COPY NUMBER ALTERATIONS IN THE MALIGNANT TRANSFORMATION OF ORAL LEUKOPLAKIA: A SYSTEMATIC REVIEW AND

Nome do Apresentador: Alini Cardoso SOARES

Categoria do Trabalho: Painel de Revisões narrativas ou sistemáticas (PRN)

Área Temática: Estomatologia

Resumo: Objective: To evaluate the role of copy number alterations (CNAs) in predicting malignant transformation (MT) of oral leukoplakia (OL).
Study Design: A systematic search was conducted across five databases and gray literature. Risk of bias was assessed using the National Heart, Lung, and Blood Institute (NHLBI) quality assessment tools. Data synthesis included a multilevel logistic regression, and a random effect meta-analysis using aggregated study data.
Results: Six studies met the eligibility criteria. Two studies were included in the logistic regression and four studies in the meta-analysis. Regarding the regression, the presence of CNAs increased the risk of malignancy by 5.55 times (OR=5.55; 95% CI[1.84-16.78; p=0.002]). Genomic losses conferred a 10-fold higher risk of MT (OR=10.00; 95% CI[1.70-58.88; p=0.009]), while gains showed a 4.35-fold; (OR=4.35; 95% CI [1.35-13.99; p=0.009]). In the meta-analysis, the presence of CNAs was significantly associated with the MT of OLs (RR 2.93 [95%CI=1.48-4.38]). Risk of bias in the studies was moderate to high.
Conclusion: This systematic review emphasizes the prognostic importance of CNAs in OL, highlighting its potential as a tool for risk stratification.

Autor 1:  Alini Cardoso SOARES

E-mail 1:  [email protected]

Autor 2:   Lauren Frenzel SCHUCH

E-mail 2:  [email protected]

Autor 3 :  Felipe Martins SILVEIRA

E-mail 3:  [email protected]

Autor 4:  Ronell Bologna MOLINA

E-mail 4:  [email protected]

Autor 5:  Luiz Alexandre CHISINI

E-mail 5:  [email protected]

Autor 6:  Ana Carolina Uchoa VASCONCELOS

E-mail 6:  [email protected]