NUMERO: #20250268

Título: Aggressive Late Recurrence of Mandibular Rhabdomyosarcoma: A Case Report

Nome do Apresentador: Nicolly Dias Dos SANTOS

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Odontologia hospitalar

Resumo: A 14-year-old female was diagnosed with mandibular rhabdomyosarcoma, presenting with preauricular pain, lower left lip numbness, and a 13 mm lytic lesion on the mandibular ramus. She underwent chemotherapy (Ifosfamide, Vincristine, Doxorubicin) and radiotherapy (54 Gy); however, disease progression was observed, leading to surgical resection followed by an additional 15 Gy of radiation for residual disease. Ten years later, she developed chin numbness and a nodular lesion. MRI revealed an infiltrative mass with mandibular erosion and C2 vertebral involvement, confirmed as metastasis. She underwent further chemotherapy (Carboplatin, Vinorelbine, Temsirolimus) and re-irradiation (50 Gy) for recurrence. Progressive disease required additional systemic therapies (Gemcitabine, Docetaxel, Temsirolimus, Nivolumab, Bevacizumab, Pembrolizumab). Severe treatment-related toxicities ensued, and the patient died from disease progression and respiratory failure. This case underscores the risk of late recurrence and aggressive progression in head and neck rhabdomyosarcoma, emphasizing the importance of long-term follow-up and tailored multimodal therapy.

Autor 1:  Nicolly Dias Dos SANTOS

E-mail 1:  [email protected]

Autor 2:   Jessica dos Santos RODRIGUES

E-mail 2:  [email protected]

Autor 3 :  Mariana Henriques FERREIRA

E-mail 3:  [email protected]

Autor 4:  Juliana Mota SIQUEIRA

E-mail 4:  [email protected]

Autor 5:  Anna Luíza Damaceno ARAÚJO

E-mail 5:  [email protected]

Autor 6:  Letícia Mello BEZINELLI

E-mail 6:  [email protected]

Autor 7:  Fernanda de Paula EDUARDO

E-mail 7:  [email protected]