NUMERO: #20250241

Título: Extensively invasive carcinoma ex-pleomorphic adenoma of high-grade myoepithelial cells: case report

Nome do Apresentador: Natasha Araújo MOTA

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Patologia Oral

Resumo: Carcinoma ex-pleomorphic adenoma is an epithelial and/or myoepithelial neoplasm that arises in association with a primary or recurrent pleomorphic adenoma (PA). This study reports a 79-year-old male patient who presented in 2017 with a nodular, floating lesion on the right hard palate. A thin-needle aspiration was performed, which suggested PA. Then, an incisional biopsy confirmed the diagnosis of PA. In 2024, the patient returned reporting a progressively enlarging mass in the oropharyngeal region, and an excisional biopsy was performed. Microscopic examination revealed a glandular neoplasm characterized by a proliferation of myoepithelial cells arranged in solid blocks, which occasionally lost cohesion, resulting in irregular spaces. There were areas exhibiting squamous metaplasia, with individual cells vacuolated and prominent nucleoli. Immunohistochemical markers showed positivity for cytokeratin, p63 protein, SOX10, calponin, S100, confirming an extensively invasive carcinoma ex-pleomorphic adenoma of high-grade myoepithelial cells. The patient was referred for oncological intervention, and remains under follow-up.

Autor 1:  Natasha Araújo MOTA

E-mail 1:  [email protected]

Autor 2:   Augusto Arcemiro BITTENCOURT

E-mail 2:  [email protected]

Autor 3 :  Jéssika Brito da COSTA

E-mail 3:  [email protected]

Autor 4:  Fábio Luiz CORACIN

E-mail 4:  [email protected]

Autor 5:  Tiago Novaes PINHEIRO

E-mail 5:  [email protected]

Autor 6:  Lucileide Castro de Oliveira MOREIRA

E-mail 6:  [email protected]

Autor 7:  Tatiana Nayara LIBÓRIO-KIMURA

E-mail 7:  [email protected]