NUMERO: #20250229

Título: NEONATAL PEMPHIGUS VULGARIS: A CASE REPORT

Nome do Apresentador: Ilan Hudson Gomes de SANTANA

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Dermatologia

Resumo: Pemphigus vulgaris (PV) is an autoimmune disease characterized by IgG autoantibodies
against desmogleins 1 and/or 3, leading to acantholysis and the formation of intraepidermal
blisters. In neonates, it occurs through passive transplacental transfer of these antibodies and
is generally transient. Although self-limited, neonatal pemphigus requires early diagnosis to
differentiate it from other severe dermatoses. We describe a case of PV in a newborn. The
mother presented with blistering lesions on the tongue, oral mucosa, breasts, and skin, while
the newborn exhibited ulcerated lesions in the genital, axillary, and posterior neck regions.
The diagnosis was confirmed by incisional biopsy and histopathology, which revealed
suprabasal cleavage, a "tombstone" pattern, and a lymphocytic inflammatory infiltrate.
Prednisolone was administered at a dose of 100 mg/day for 14 days, with progressive
improvement and the newborn, had a good improvement. Conclusion: This case reinforces the
importance of early diagnosis and clinical surveillance in neonates exposed to maternal
autoantibodies.

Autor 1:  Ilan Hudson Gomes de SANTANA

E-mail 1:  [email protected]

Autor 2:   Helder Domiciano Dantas Martins

E-mail 2:  [email protected]

Autor 3 :  Daniele Medeiros Marques

E-mail 3: 

Autor 4:  Ianna Gil de Farias Morais

E-mail 4: 

Autor 5:  Laura Rolim de Carvalho Nóbrega

E-mail 5: 

Autor 6:  Sheila Katchir de Paulo Oliveira

E-mail 6: 

Autor 7:  Paulo Rogério Ferreti Bonan

E-mail 7:  [email protected]