NUMERO: #20250213

Título: "SCLEROTIC BENIGN FIBROUS HISTIOCYTOMA-LIKE" SCLEROTIC FIBROMA OF THE ORAL MUCOSA: A DETAILED IMMUNOHISTOCHEMICAL STUDY

Nome do Apresentador: Karina Helen MARTINS

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Patologia Oral

Resumo: Sclerotic fibroma (SF), originally recognized as a cutaneous manifestation of Cowden syndrome (CS), is an uncommon, well-circumscribed tumor presenting sclerotic, hyalinized collagen bundles. Initially considered a sclerotic variant of benign fibrous histiocytoma (BFH), as well as studies showing SF-like BFHs and SF-like changes in cutaneous lesions, potential diagnostic pitfall and/or overlap when assessing SF exists. However, advances in immunohistochemistry, in strict histomorphological correlation, allow for correct diagnosis. To date, about 12 intraoral SFs have been reported, all but one without CS association. We report a comprehensive immunohistochemical panel of a typical SF affecting the buccal mucosa of a 46-year-old male patient, without CS association. By immunohistochemistry, vimentin, CD34, CD99, collagen-IV (focal), and α-SMA (focal), were positive. Notably, CD68, CD163, FXIIIA, and lysozyme, highlighted an infiltrating histiocytic population. The current case emphasizes that histomorphological analysis, as well as distinctive CD34 and CD99 expression, allows differentiating SF from BFH in most cases.

Autor 1:  Karina Helen MARTINS

E-mail 1:  [email protected]

Autor 2:   Gabriela Esperanza Maradiaga POSANTES

E-mail 2:  [email protected]

Autor 3 :  Thales Peres Candido MOREIRA

E-mail 3:  [email protected]

Autor 4:  Marcelo Borges MARQUES

E-mail 4:  [email protected]

Autor 5:  Heitor Albergoni da SILVEIRA

E-mail 5:  [email protected]

Autor 6:  Fernando CHAHUD

E-mail 6:  [email protected]

Autor 7:  Jorge Esquiche LEÓN

E-mail 7:  [email protected]