NUMERO: #20250196

Título: NONINVASIVE DIAGNOSIS THROUGH SALIVARY BIOMARKERS: AN INTEGRATIVE REVIEW OF MULTIOMICS APPROACHES

Nome do Apresentador: Ana Claudia Garcia ROSA

Categoria do Trabalho: Painel de Revisões narrativas ou sistemáticas (PRN)

Área Temática: Áreas afins no caráter multidisciplinar

Resumo: Objective: To synthesize current evidence on salivary biomarkers associated with oral squamous cell carcinoma (OSCC), periodontal disease (PD), Sjögren's syndrome (SS), and oral potentially malignant disorders (OPMDs), highlighting their clinical diagnostic potential.
Study Design: This integrative review included studies published in the last 10 years retrieved from PubMed, Scopus, and Web of Science, focusing on salivaomics-based biomarkers related to oral diseases.
Results: Salivaomics technologies (genomics, transcriptomics, proteomics, metabolomics, and microbiomics) have enabled the identification of disease-specific salivary biomarkers. In OSCC, biomarkers such as IL-1α, IL-1β, IL-6, IL-8, TNF-α, VEGF, MMP-1, MMP-9, microRNAs, and epigenetic markers (MGMT, DAPK1, RASSF1A), along with metabolic markers and oral microbiome changes (e.g., F. nucleatum, P. gingivalis), are linked to tumorigenesis. In OPMDs, inflammatory cytokines (TNF-α, IL-6, IL-8), oxidative stress markers, and MMP-9 indicate risk of malignant transformation. PD is associated with IL-1β, MMP-8, TNF-α, RANKL, and OPG. In SS, altered cytokine profiles reflect immune-mediated dysfunction.
Conclusion: Salivary biomarkers show great promise as noninvasive diagnostic tools. However, challenges remain in standardization and validation for clinical use. Future perspectives include integrating multiomics technologies and AI-driven analyses to improve accuracy and reliability in diagnosing oral and systemic diseases.

Autor 1:  Ana Claudia Garcia ROSA

E-mail 1:  [email protected]

Autor 2:   Marcos Phelipe Araujo Andrade ALVES

E-mail 2:  [email protected]