NUMERO: #20250166

Título: INTRAORAL SALIVARY DUCT CARCINOMA WITH PROMINENT CLEAR CYTOPLASMIC VACUOLE AND STROMAL SCLEROSIS WITH ELASTOFIBROMATOSIS

Nome do Apresentador: Mariana Paravani PALAÇON

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Patologia Oral

Resumo: Salivary duct carcinoma (SDC) is a rare and aggressive malignancy, predominantly affecting the parotid glands of adult males, with intraoral involvement being uncommon. A 66-year-old male was referred presenting a large tumor mass on the left buccal over several months, initially diagnosed as high-grade mucoepidermoid carcinoma. Upon re-evaluation, microscopic analysis revealed extensive stromal sclerosis with foci of elastosis occupying about 85% of the tumor area, alongside discrete tumor nests with pleomorphic and hyperchromatic nuclei and numerous clear cytoplasmic vacuoles. Comedo-type necrosis and apocrine differentiation were not evident. Immunohistochemistry showed strong positivity for CK7, GCDFP-15, GATA3, and androgen receptor. HER2 IHC indicated a 2+ score, and HER2 FISH evidenced significant amplification in over 50% of cells. The p53 IHC pattern was abnormal ("null"), and the Ki-67 proliferative index was 30%. The diagnosis was consistent with sclerosing SDC. After 16 months of follow-up, the patient remains well, without recurrences.

Autor 1:  Mariana Paravani PALAÇON

E-mail 1:  [email protected]

Autor 2:   Heitor Albergoni SILVEIRA

E-mail 2:  [email protected]

Autor 3 :  Luana Stefanie Silvino GONÇALVES

E-mail 3:  [email protected]

Autor 4:  Karina Helen MARTINS

E-mail 4:  [email protected]

Autor 5:  Mariângela Ottoboni BRUNALDI

E-mail 5:  [email protected]

Autor 6:  Fernando CHAHUD

E-mail 6:  [email protected]

Autor 7:  Jorge Esquiche LEÓN

E-mail 7:  [email protected]