NUMERO: #20250111

Título: ADENOCARCINOMA NOT OTHERWISE SPECIFIED OF THE TONGUE: A DIAGNOSTIC CHALLENGE

Nome do Apresentador: Kallana MEZZOMO Faccin

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Patologia Oral

Resumo: Adenocarcinoma not otherwise specified (ACNOS) is a rare malignant tumor of the salivary glands that requires detailed microscopic evaluation and exclusion of other entities for an accurate diagnosis. A 42-year-old female patient presented to the dental service with a normochromic, smooth-surfaced nodule on the ventral surface of the tongue, measuring 15 mm, with a two-month history. The clinical differential diagnosis initially suggested a reactive lesion. After biopsy, microscopic examination revealed a malignant neoplasm of glandular origin, characterized by columnar epithelial cells exhibiting nuclear pleomorphism. Ductal differentiation and cystic areas were also observed. Immunohistochemical analysis showed tumor cell positivity for CD117, AE1/AE3, and CK7, while p40, p63, GATA3, and S100 were negative. Ki-67 expression was detected in 10% of the tumor cells. A definitive diagnosis of ACNOS was established. The patient was subsequently referred to a cancer center and remains under clinical follow-up.

Autor 1:  Kallana MEZZOMO Faccin

E-mail 1:  [email protected]

Autor 2:   Georgia MARTINI

E-mail 2:  [email protected]

Autor 3 :  Júlia Turra RIBEIRO

E-mail 3:  [email protected]

Autor 4:  Grasieli de Oliveira RAMOS

E-mail 4:  [email protected]

Autor 5:  Daniella Sarafin Couto VIEIRA

E-mail 5:  [email protected]

Autor 6:  Ricardo Luiz Cavalcanti de ALBUQUERQUE-JÚNIOR

E-mail 6:  [email protected]

Autor 7:  Rogério GONDAK

E-mail 7:  [email protected]