NUMERO: #20250074

Título: SOLITARY MANDIBULAR PLASMACYTOMA WITH ATYPICAL IMMUNOPHENOTYPE: A RARE DIAGNOSTIC CHALLENGE

Nome do Apresentador: Laryssa Thainá Mello Queiroz Cunha

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Estomatologia

Resumo: A 42-year-old male patient presented with a two-month history of numbness in the posterior mandibular region. Clinical examination revealed mild swelling in the right mandibular body, with swelling of the vestibular sulcus. Imaging studies showed a poorly defined hypodense lesion, associated with cortical bone thinning and disruption. Suspecting of a malignant neoplasm, an incisional biopsy was performed. Histopathological examination revealed a proliferation of plasma cells in a poorly vascularized stroma. Immunohistochemical analysis was positive for CD79, CD56, Plasma Cell, MUM-1, and lambda light chain, with a proliferative index of 10%. CD138 expression and in situ hybridization for Epstein-Barr virus were negative. The initial diagnosis was solitary intraosseous plasmacytoma versus multiple myeloma. The patient was referred for oncologic staging. A PET-CT scan showed no additional lesions, confirming the diagnosis of solitary bone plasmacytoma. Treatment consisted of exclusive radiotherapy leading to complete resolution. The patient remains disease-free after one year of follow-up.

Autor 1:  Laryssa Thainá Mello Queiroz Cunha

E-mail 1:  [email protected]

Autor 2:   Hélen Kaline Farias Bezerra

E-mail 2:  [email protected]

Autor 3 :  Brenda Corrêa Santos

E-mail 3:  [email protected]

Autor 4:  Daniel Lobato Ferreira Ferras

E-mail 4:  [email protected]

Autor 5:  Ivan José Correia Neto

E-mail 5:  [email protected]

Autor 6:  Pablo Agustin Vargas

E-mail 6:  [email protected]

Autor 7:  Márcio Ajudarte Lopes

E-mail 7:  [email protected]