NUMERO: #20240163

Título: EVALUATION OF THE CORRELATION BETWEEN SALIVARY METABOLITES OF CONVENTIONAL CIGARETTE SMOKERS, CLINICAL DATA, AND TOBACCO

Nome do Apresentador: Lurye Silva THEODORO

Categoria do Trabalho: Painel de pesquisa científica (PPC)

Área Temática: Estomatologia

Resumo: Objective: The study aimed to assess the salivary metabolomic profile of cigarette smokers and examine the correlation of changes with clinical data and tobacco consumption. Study Design: The study included 26 frequent and exclusive smokers of industrialized cigarettes in the cigarette group, while the control group consisted of non-smokers. Unstimulated total saliva was collected for analysis. Metabolic profile data were obtained using gas chromatography coupled to a mass spectrometer, and correlations were made with cotinine levels measured by an immunoenzymatic test, as well as with clinical data using statistical analysis in the MetaboAnalyst 6.0 platform. Results: The partial least squares-discriminant analysis showed significant separation between the cigarette group and the control group. The volcano plot analysis revealed 31 statistically relevant metabolites (p value ≤0.05) for correlation with clinical data and tobacco consumption among smokers. Notably, glyceraldehyde stood out due to its mutagenic properties. Conclusion: Evaluating the salivary metabolome of smokers can serve as an important tool for understanding biomarkers associated with smoking.
Acknowledgments: We gratefully acknowledge the São Paulo State Research Foundation (FAPESP) for supporting grant #2018/23248-1 and the Coordination of Higher Level Staff Improvement (CAPES) for the masters scholarship.

Autor 1:  Lurye Silva THEODORO

E-mail 1:  [email protected]

Autor 2:   David Aciole BARBOSA

E-mail 2:  [email protected]

Autor 3 :  Ellen GREENFIELD

E-mail 3:  [email protected]

Autor 4:  Desiree Rosa CAVALCANTI

E-mail 4:  [email protected]

Autor 5:  Maria Anita MENDES

E-mail 5:  [email protected]

Autor 6:  Fabiano Bezerra MENEGIDIO

E-mail 6:  [email protected]

Autor 7:  Mônica Ghislaine Oliveira ALVES

E-mail 7:  [email protected]