NUMERO: #20230026

Título: ANTI-CANDIDA AND ANTI-CANCER PEPTIDES: A SYSTEMATIC REVIEW OF A NOVEL DUAL-FUNCTION PHARMACOLOGICAL PROPOSAL

Nome do Apresentador: Gabriela Jacób MONTEIRO

Categoria do Trabalho: Painel de Revisões narrativas ou sistemáticas (PRN)

Área Temática: Oncologia

Resumo: Objective: To explore active peptides against both opportunistic oral infection by Candida spp. and oral squamous cell carcinoma (OSCC). Study design: A systematic review using MeSH/PUBMED and Scielo databases was conducted analyzing publications which observed the proposed objective, following the PRISMA statement. The descriptors "Candida", "oral neoplasm" and "antimicrobial peptides" were articulated to obtain the studies. From a total of 113 publications, 5 fulfilled the adopted criteria. Results: Chronic hyperplasia caused by Candida spp. constitutes a potentially malignant lesion, which leads to carcinogenesis. OSCC, on the other hand, represents a risk factor for oropharyngeal candidiasis. Faced with the usual resistance demonstrated against drugs for the treatment of both conditions, dual-function peptides highlight, presenting a selective membranolytic potential, against which there is low or no resistance. Thereby, peptides as CAMP/LL-37 and Hp-MAP3, despite inducing some hemolytic activity, showed off to be promising for treatment of both diseases. Conclusion: Data suggest that CAMP/LL-37 and Hp-MAP3 appear as potential drugs to treat opportunistic oral infection by Candida spp. and OSCC. However, further work is needed to support its dual-function capacity. Our research group is redesigning, synthesizing and testing peptides, hopefully leading to new candidates to treat Candida spp. and OSCC.

Autor 1:  Gabriela Jacób MONTEIRO

E-mail 1:  [email protected]

Autor 2:   Eduarda Fernandes LEAL

E-mail 2:  [email protected]

Autor 3 :  Carla Silva Siqueira MIRANDA

E-mail 3:  [email protected]

Autor 4:  Esteban Nicolas LORENZON

E-mail 4:  [email protected]