NUMERO: #20230001

Título: NECROTIZING SIALOMETAPLASIA OF SOFT PALATE: IT IS STILL A DIAGNOSTIC DILLEMA

Nome do Apresentador: Caio Cesar de Souza LOUREIRO

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Estomatologia

Resumo: Necrotizing sialometaplasia (NSM) is a rare self-limited lesion of salivary glands, which can be easily misdiagnosed as a malignant neoplasm, as mucoepidermoid and squamous cell (SCC) carcinomas. We herein report a case of NSM in a 45-year-old man presenting a soft palate ulcer with the diagnostic hypothesis of syphilis or SCC. After an incisional biopsy, histological sections revealed a fragment lined by hyperplastic squamous epithelium with drop-shaped rete ridges and disorganization of the basal layer. Extensive ulcerated area and small nests of squamous cells with slight cellular atypia and mitotic figures were observed beneath it, as well as ducts and small groups of mucous and squamous cells. Immunohistochemistry for calponin and smooth muscle actin demonstrated myoepithelial cells surrounding the epithelial islands. Complete resolution was observed after 5 weeks, confirming the diagnosis of NSM. Awareness of similarities of this lesion with malignant neoplasms is important to avoid diagnostic pitfalls and mistreatment.

Autor 1:  Caio Cesar de Souza LOUREIRO

E-mail 1:  [email protected]

Autor 2:   Alberi José Thomas de SOUZA JÚNIOR

E-mail 2: 

Autor 3 :  Patrícia Bitencourt DA ROCHA

E-mail 3: 

Autor 4:  Jaqueline Lemes RIBEIRO

E-mail 4: 

Autor 5:  Ana Lia ANBINDER

E-mail 5:  [email protected]